Stacks by Evidence Grade

Sorted by evidence grade ascending. Most stacks sit at Grade C — preclinical evidence with limited or indirect human translation.

Educational research-literacy content only. Not medical advice, not dosing guidance, not sourcing advice, and not a protocol for human or animal use. See our responsible information policy.

Combination evidence is rarer and weaker than monotherapy evidence. That is why most stacks on this site sit at Grade C or below: the combination is the claim, and the combination is rarely directly studied. Where a stack contains a UK-approved or approved-elsewhere compound (Tirzepatide, Tesamorelin, PT-141), the individual peptide is graded higher, but the combination as used in the stack inherits the conservative default. Read this table alongside our A–X grading methodology and the direct vs inferred combination explainer.