Direct Combination Evidence Matrix
The honest disclosure for every stack on the site.
Educational research-literacy content only. Not medical advice, not dosing guidance, not sourcing advice, and not a protocol for human or animal use. See our responsible information policy.
Most combinations on this site have no direct combination evidence — their rationale is inferred from monotherapy literature on the individual peptides. The exceptions are the BPC-157 + TB-500 family of stacks (multiple rodent tissue-repair studies) and the CJC-1295 + Ipamorelin family (small human PK / GH-release studies of the pair). Every other stack is graded as inferred. This is the most useful matrix to read first if you want to understand how confident a given combination claim should make you. See: direct vs inferred stacks and why synergy is often assumed, not demonstrated.
| Stack | Direct combo evidence | Human data | Grade | Main uncertainty |
|---|---|---|---|---|
| BPC-157 + TB-500 + GHK-Cu — Research Evidence Review: Tissue-Repair & Remodelling Mechanisms | limited | limited | C | Direct combination evidence is limited (mostly preclinical / small-trial). |
| BPC-157 + TB-500 — Research Evidence Review: Tissue-Repair Mechanisms & Translational Limits | limited | limited | C | Direct combination evidence is limited (mostly preclinical / small-trial). |
| CJC-1295 + Ipamorelin + Tesamorelin — Research Evidence Review: GH Axis Mechanisms & Study Limitations | limited | limited | C | Direct combination evidence is limited (mostly preclinical / small-trial). |
| Ipamorelin + CJC-1295 + BPC-157 — Research Evidence Review: GH Axis + Tissue-Repair Mechanisms | limited | limited | C | Direct combination evidence is limited (mostly preclinical / small-trial). |
| TB-500 + BPC-157 — Research Evidence Review: Tendon Repair Mechanisms & Study Models | limited | limited | C | Direct combination evidence is limited (mostly preclinical / small-trial). |
| BPC-157 + GHK-Cu — Research Evidence Review: Follicular Mechanisms & Evidence Limits | no | no | D | No direct combination studies; mechanism is inferred from monotherapy literature. |
| BPC-157 + KPV + Thymosin α-1 — Research Evidence Review: Immune & Mucosal Mechanisms | no | indirect | C | No direct combination studies; mechanism is inferred from monotherapy literature. |
| Cerebrolysin + Semax — Research Evidence Review: Neuropeptide & BDNF-Axis Mechanisms | no | indirect | C | No direct combination studies; mechanism is inferred from monotherapy literature. |
| DSIP + Selank — Research Evidence Review: Sleep & Anxiolytic Mechanisms | no | indirect | C | No direct combination studies; mechanism is inferred from monotherapy literature. |
| Epitalon + Humanin + MOTS-c — Research Evidence Review: Mitochondrial & Telomeric Mechanisms | no | indirect | C | No direct combination studies; mechanism is inferred from monotherapy literature. |
| Epithalon + Thymalin — Research Evidence Review: Khavinson Bioregulator Mechanisms | no | indirect | C | No direct combination studies; mechanism is inferred from monotherapy literature. |
| GHK-Cu + TB-500 — Research Evidence Review: Dermal Remodelling Mechanisms | no | no | D | No direct combination studies; mechanism is inferred from monotherapy literature. |
| KPV + LL-37 — Research Evidence Review: Mucosal & Antimicrobial Mechanisms | no | no | D | No direct combination studies; mechanism is inferred from monotherapy literature. |
| MOTS-c + AOD-9604 — Research Evidence Review: Mitochondrial & Lipolytic Mechanisms | no | no | D | No direct combination studies; mechanism is inferred from monotherapy literature. |
| Melanotan II + Bremelanotide — Research Evidence Review: Melanocortin Mechanisms & Safety Signals | no | indirect | C | No direct combination studies; mechanism is inferred from monotherapy literature. |
| PT-141 + Kisspeptin-10 — Research Evidence Review: Melanocortin & Reproductive-Axis Mechanisms | no | indirect | C | No direct combination studies; mechanism is inferred from monotherapy literature. |
| SS-31 + Humanin — Research Evidence Review: Mitochondrial Mechanisms | no | no | D | No direct combination studies; mechanism is inferred from monotherapy literature. |
| SS-31 + MOTS-c — Research Evidence Review: Mitochondrial Cardiovascular Mechanisms | no | no | D | No direct combination studies; mechanism is inferred from monotherapy literature. |
| Semax + Selank + Pinealon — Research Evidence Review: Neuropeptide Mechanisms & Translational Limits | no | indirect | C | No direct combination studies; mechanism is inferred from monotherapy literature. |
| Tesamorelin + AOD-9604 — Research Evidence Review: Visceral Adipose Research Context | no | indirect | C | No direct combination studies; mechanism is inferred from monotherapy literature. |
| Tirzepatide + Retatrutide + AOD-9604 — Research Evidence Review: Incretin & Lipolytic Mechanisms (UK POM sensitivity) | no | indirect | C | No direct combination studies; mechanism is inferred from monotherapy literature. |